Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2014

Heitzeg Mary M, Villafuerte Sandra, Weiland Barbara J, Enoch Mary-Anne, Burmeister Margit, Zubieta Jon-Kar, Zucker Robert A

Abstract excerpt

Heightened reactivity of the incentive-motivation system has been proposed to underlie adolescent-typical risky behaviors, including problem alcohol involvement. However, even in adolescence considerable individual variation in these behaviors exists, which may have genetic underpinnings and be related to variations in risk for later alcohol use disorder (AUD). Variants in GABRA2 have been associated with adult...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcoholism
Share to Analysis of Variance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Developmental Disabilities

Share to Image Processing, Computer-Assisted

Share to Linear Models

Share to Motivation

Share to Oxygen

Share to Receptors, GABA-A

Source

Open in PubMed Open full text

Identifiers

PMID: 24975023
DOI: 10.1038/npp.2014.161
PMCID: PMC4229579

Genes

GABRA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk.PMID 24975023Read ↗

Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence.Semantic proximity Read ↗

RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release.Semantic proximity Read ↗

Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents.Semantic proximity Read ↗

A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.Semantic proximity Read ↗

Reward Region Responsivity Predicts Future Weight Gain and Moderating Effects of the TaqIA Allele.Semantic proximity Read ↗

Reward Sensitivity of ACC as an Intermediate Phenotype between DRD4-521T and Substance MisuseSemantic proximity Read ↗

Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.Semantic proximity Read ↗

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.Semantic proximity Read ↗

Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.Semantic proximity Read ↗

The contribution of imaging genetics to the development of predictive markers for addictions.Semantic proximity Read ↗

Identifying neurobiological phenotypes associated with alcohol use disorder severity.Semantic proximity Read ↗

The incentive salience of alcohol: translating the effects of genetic variant in CNR1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.