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Article

Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions.

Brain research reviews - 1 Jan 2011

Perry Jennifer L, Joseph Jane E, Jiang Yang, Zimmerman Rick S, Kelly Thomas H, Darna Mahesh, Huettl Peter, Dwoskin Linda P, Bardo Michael T

Abstract excerpt

Vulnerability to drug abuse is related to both reward seeking and impulsivity, two constructs thought to have a biological basis in the prefrontal cortex (PFC). This review addresses similarities and differences in neuroanatomy, neurochemistry and behavior associated with PFC function in rodents and humans. Emphasis is placed on monoamine and amino acid neurotransmitter systems located in anatomically distinct...

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Source

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Identifiers

PMID: 20837060
DOI: 10.1016/j.brainresrev.2010.09.001
PMCID: PMC3005953

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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