A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.

doi:10.1016/j.euroneuro.2018.07.101

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Article

A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2018

Macare Christine, Ducci Francesca, Zhang Yuning, Ruggeri Barbara, Jia Tianye, Kaakinen Marika, Kalsi Gursharan, Charoen Pimphen, Casoni Filippo, Peters Jan, Bromberg Uli, Hill Matthew, Buxton Jessica, Blakemore Alexandra, Veijola Juha, Büchel Christian, Banaschewski Tobias, Bokde Arun L W, Conrod Patricia, Flor Herta, Frouin Vincent, Gallinat Jürgen, Garavan Hugh, Gowland Penny A, Heinz Andreas, Ittermann Bernd, Lathrop Mark, Martinot Jean-Luc, Paus Tomáš, Desrivières Sylvane, Munafò Marcus, Järvelin Marjo-Riitta, Schumann Gunter

Abstract excerpt

The TTC12-ANKK1-DRD2 gene-cluster has been implicated in adult smoking. Here, we investigated the contribution of individual genes in the TTC12-ANKK1-DRD2 cluster in smoking and their association with smoking-associated reward processing in adolescence. A meta-analysis of TTC12-ANKK1-DRD2 variants and self-reported smoking behaviours was performed in four European adolescent cohorts (N = 14,084). The minor...

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Identifiers

PMID: 30104163
DOI: 10.1016/j.euroneuro.2018.07.101
PMCID: PMC6525784

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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