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Article

Characterizing dopaminergic neuron vulnerability using genome-wide analysis.

Genetics - 9 Aug 2021

Davis Jacinta, Da Silva Santos Claire, Zavala Narda Caudillo, Gans Nicholas, Patracuolla Daniel, Fehrenbach Monica, Babcock Daniel T

Abstract excerpt

Parkinson's disease (PD) is primarily characterized by the loss of dopaminergic (DA) neurons in the brain. However, little is known about why DA neurons are selectively vulnerable to PD. To identify genes that are associated with DA neuron loss, we screened through 201 wild-caught populations of Drosophila melanogaster as part of the Drosophila Genetic Reference Panel. Here, we identify the top-associated genes...

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Identifiers

PMID: 34038543
DOI: 10.1093/genetics/iyab081
PMCID: PMC8864742

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