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Benzothiazepinecarboxamides: Novel hepatitis C virus inhibitors that interfere with viral entry and the generation of infectious virions.

Antiviral research - 1 May 2016

Kim Hee-Young, Kong Sunju, Oh Sangmi, Yang Jaewon, Jo Eunji, Ko Yoonae, Kim Soo-Hyun, Hwang Jong Yeon, Song Rita, Windisch Marc P

Abstract excerpt

Upon screening synthetic small molecule libraries with the infectious hepatitis C virus (HCV) cell culture system, we identified a benzothiazepinecarboxamide (BTC) scaffold that inhibits HCV. A structure-activity relationship (SAR) study with BTCs was performed, and modifications that led to nanomolar antiviral activity and improved the selective index (CC50/EC50) by more than 1000-fold were identified. In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26850830
DOI: 10.1016/j.antiviral.2016.01.010

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BTC

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