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Article

Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents.

Bioorganic & medicinal chemistry - 1 Jan 2021

Gu Xiaoke, Zhang Yinpeng, Zou Yueting, Li Xin, Guan Mingyu, Zhou Qingqing, Qiu Jingying

Abstract excerpt

As a continuation of our previous work, a series of new phenyl acrylamide derivatives (4Aa-g, 4Ba-t, 5 and 6a-c) were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound 4Bs could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18 μM, respectively. Notably, the selective index value of 4Bs was...

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PMID: 33285406
DOI: 10.1016/j.bmc.2020.115892

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