Article
Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.
Scientific reports - 13 Feb 2017
Zhou Zheng, Hu Taishan, Zhou Xue, Wildum Steffen, Garcia-Alcalde Fernando, Xu Zhiheng, Wu Daitze, Mao Yi, Tian Xiaojun, Zhou Yuan, Shen Fang, Zhang Zhisen, Tang Guozhi, Najera Isabel, Yang Guang, Shen Hong C, Young John A T, Qin Ning
Abstract excerpt
Heteroaryldihydropyrimidine (HAP) and sulfamoylbenzamide (SBA) are promising non-nucleos(t)ide HBV replication inhibitors. HAPs are known to promote core protein mis-assembly, but the molecular mechanism of abnormal assembly is still elusive. Likewise, the assembly status of core protein induced by SBA remains unknown. Here we show that SBA, unlike HAP, does not promote core protein mis-assembly. Interestingly,...
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