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Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic

22 Sept 2024

Abstract excerpt

Chronic hepatitis B is a global health concern with a high risk of end-stage liver disease. Current standard-of-care agents have low cure rates, and new therapies are needed. Small interfering RNAs (siRNAs) that target viral RNAs fulfill a gap not addressed by standard-of-care agents and may contribute to a functional cure. Here, we describe the preclinical characterization of imdusiran (AB-729), a novel,...

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PMID: 39306863
DOI: 10.1021/acsinfecdis.4c00514

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