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Article

Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.

Journal of medicinal chemistry - 25 Aug 2011

Yu Wenquan, Goddard Cally, Clearfield Elizabeth, Mills Courtney, Xiao Tong, Guo Haitao, Morrey John D, Motter Neil E, Zhao Kang, Block Timothy M, Cuconati Andrea, Xu Xiaodong

Abstract excerpt

The high levels of hepatitis B virus (HBV) surface antigen (HBsAg)-bearing subviral particles in the serum of chronically infected individuals play an important role in suppressing HBV-specific immune response and are only mildly affected by the current small molecule therapies. Thus, a therapy t...

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Identifiers

PMID: 21786803
DOI: 10.1021/jm200696v
PMCID: PMC3158247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21786803-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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