Article
Genetic variants in the regulatory region of SLC10A1 are not associated with the risk of hepatitis B virus infection and clearance.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Oct 2016
Chen Xueqin, Wang Ying, Chen Xiaohua, Cheng Kailiang, Li Jiaoyuan, Lou Jiao, Ke Juntao, Yang Yang, Gong Yajie, Zhu Ying, Wang Li, Zhong Rong
Abstract excerpt
The Na/taurocholate cotransporter NTCP (encoded by SLC10A1) was identified as a cellular entry receptor for the human hepatitis B virus (HBV), advancing our understanding of the molecular mechanism of HBV infection. An alternative hypothesis was put forward that regulatory variants in SLC10A1 might play an important role in HBV susceptibility by potentially influencing expression levels of NTCP. The three...
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