Article
Reductions in cross-neutralizing antibody responses in infants after attenuation of the human rotavirus vaccine candidate 89-12.
The Journal of infectious diseases - 15 Dec 2006
Ward Richard L, Kirkwood Carl D, Sander Donna S, Smith Vicki E, Shao Mingyuan, Bean Judy A, Sack David A, Bernstein David I
Abstract excerpt
The G1P1A[8] rotavirus vaccine candidate 89-12, the precursor to Rotarix, stimulated high titers of neutralizing antibodies to non-G1/P1A[8] serotypes of human rotavirus in naturally infected subjects before attenuation by cell-culture passages. These responses were greatly diminished in young infants (median age, 11 weeks) administered the attenuated vaccine. Because of the possibility of improved responses in...
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