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Article

Stable Salmonella live vaccine strains with two or more attenuating mutations and any desired level of attenuation.

Vaccine - 1 Jun 1990

Linde K, Beer J, Bondarenko V

Abstract excerpt

Mutants optimally attenuated for highly susceptible hosts and protecting after a single oral vaccination are often overattenuated for host species being less susceptible. Therefore, to select vaccine strains optimally attenuated for the particular host species it is essential that a range of mutants with graded levels of attenuation be provided so as to permit lesser susceptibility to be compensated for by a...

Topics

Animals
Bacterial Vaccines
Genetic Markers
Mice
Mice, Inbred ICR
Mutation
Salmonella
Salmonella Infections, Animal
Salmonella typhi
Salmonella typhimurium
Vaccines, Attenuated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2194381
DOI: 10.1016/0264-410x(90)90058-t

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2194381-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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