Article
Stable Salmonella live vaccine strains with two or more attenuating mutations and any desired level of attenuation.
Vaccine - 1 Jun 1990
Linde K, Beer J, Bondarenko V
Abstract excerpt
Mutants optimally attenuated for highly susceptible hosts and protecting after a single oral vaccination are often overattenuated for host species being less susceptible. Therefore, to select vaccine strains optimally attenuated for the particular host species it is essential that a range of mutants with graded levels of attenuation be provided so as to permit lesser susceptibility to be compensated for by a...
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