Article
Construction of recombinant attenuated Salmonella enterica serovar typhimurium vaccine vector strains for safety in newborn and infant mice.
Clinical and vaccine immunology : CVI - 1 Mar 2010
Gunn Bronwyn M, Wanda Soo-Young, Burshell Dana, Wang Caihong, Curtiss Roy
Abstract excerpt
Recombinant bacterial vaccines must be safe, efficacious, and well tolerated, especially when administered to newborns and infants to prevent diseases of early childhood. Many means of attenuation have been shown to render vaccine strains susceptible to host defenses or unable to colonize lymphoid tissue effectively, thus decreasing their immunogenicity. We have constructed recombinant attenuated Salmonella...
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