Article
The history of live bacterial vaccines.
Developments in biological standardization - 1 Jan 1995
Lindberg A A
Abstract excerpt
Recent developments have made it possible to construct non-reverting live bacterial vaccine candidates with defined deletions of two or more genes. Such vaccines have proven safe and immunogenic in human volunteers. Since the virulent parent strains are only pathogenic to man (S. typhi, S. flexneri, and V. cholerae), they pose no threat to the environment. Besides holding promise as efficacious vaccines for...
Topics
- Animals
- Bacterial Infections
- Bacterial Vaccines
- Genetic Vectors
- History, 19th Century
- History, 20th Century
- Humans
- Mutation
- Salmonella typhi
- Shigella
- Vaccines, Attenuated
- Vaccines, Synthetic