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Article

Multiple myeloma clonal evolution in homogeneously treated patients.

Leukemia - 1 Dec 2018

Corre Jill, Cleynen Alice, Robiou du Pont Sébastien, Buisson Laure, Bolli Niccolo, Attal Michel, Munshi Nikhil, Avet-Loiseau Hervé

Abstract excerpt

Clonal evolution drives tumor progression, chemoresistance and relapse in cancer. Little is known about clonal selection induced by therapeutic pressure in multiple myeloma. To address this issue, we performed large targeted sequencing of bone marrow plasma cells in 43 multiple myeloma patients at diagnosis and at relapse from exactly the same intensive treatment. The most frequently mutated genes at diagnosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29895955
DOI: 10.1038/s41375-018-0153-6
PMCID: PMC6603429

Genes

BRAF
DIS3
KRAS
NRAS

Provenance

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