Article
Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma.
Blood - 29 Sept 2016
Weinhold Niels, Ashby Cody, Rasche Leo, Chavan Shweta S, Stein Caleb, Stephens Owen W, Tytarenko Ruslana, Bauer Michael A, Meissner Tobias, Deshpande Shayu, Patel Purvi H, Buzder Timea, Molnar Gabor, Peterson Erich A, van Rhee Frits, Zangari Maurizio, Thanendrarajan Sharmilan, Schinke Carolina, Tian Erming, Epstein Joshua, Barlogie Bart, Davies Faith E, Heuck Christoph J, Walker Brian A, Morgan Gareth J
Abstract excerpt
To elucidate the mechanisms underlying relapse from chemotherapy in multiple myeloma, we performed a longitudinal study of 33 patients entered into Total Therapy protocols investigating them using gene expression profiling, high-resolution copy number arrays, and whole-exome sequencing. The study illustrates the mechanistic importance of acquired mutations in known myeloma driver genes and the critical nature of...
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