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Article

Ant1 mutant mice bridge the mitochondrial and serotonergic dysfunctions in bipolar disorder

7 Jun 2018

Abstract excerpt

Although mitochondrial and serotonergic dysfunctions have been implicated in the etiology of bipolar disorder (BD), the relationship between these unrelated pathways has not been elucidated. A family of BD and chronic progressive external ophthalmoplegia (CPEO) caused by a mutation of the mitochondrial adenine nucleotide translocator 1 (ANT1, SLC25A4) implicated that ANT1 mutations confer a risk of BD. Here, we...

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PMID: 29892051
DOI: 10.1038/s41380-018-0074-9

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