Article
Ntrk1 mutation co-segregating with bipolar disorder and inherited kidney disease in a multiplex family causes defects in neuronal growth and depression-like behavior in mice.
Translational psychiatry - 24 Nov 2020
Nakajima Kazuo, Miranda Alannah, Craig David W, Shekhtman Tatyana, Kmoch Stanislav, Bleyer Anthony, Szelinger Szabolcs, Kato Tadafumi, Kelsoe John R
Abstract excerpt
Previously, we reported a family in which bipolar disorder (BD) co-segregates with a Mendelian kidney disorder linked to 1q22. The causative renal gene was later identified as MUC1. Genome-wide linkage analysis of BD in the family yielded a peak at 1q22 that encompassed the NTRK1 and MUC1 genes. NTRK1 codes for TrkA (Tropomyosin-related kinase A) which is essential for development of the cholinergic nervous...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.