Bipolar disorder-associated variants in RAB5A disrupt its function in endolysosomal trafficking in fruit fly and mammalian systems

Abstract excerpt

<title>Abstract</title> <p> Bipolar disorder is a severe neuropsychiatric disorder associated with significant morbidity and mortality. Although the heritability of bipolar disorder is among the highest of all neuropsychiatric disorders, the specific genetic etiologies for most affected individuals have remained elusive. This is due, in part, to difficulty confirming pathogenicity of genomic variants identified...

Topics

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• Bipolar Disorder
• Bipolar Disorder and Treatment
• Brain
• Exome Sequencing
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Mice
• Phenotype

Identifiers and source

Literature Corpus work

283073d7-896f-5b97-9e74-9b8d37a0d68e

DOI

10.21203/rs.3.rs-10538807/v1