Article
The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms.
Neurochemistry international - 1 Sept 2020
Hidalgo Sergio, Castro Christian, Zárate Rafaella V, Valderrama Benjamín P, Hodge James J L, Campusano Jorge M
Abstract excerpt
Mutations in the dystrobrevin binding protein 1 (DTNBP1) gene that encodes for the dysbindin-1 protein, are associated with a higher risk for schizophrenia. Interestingly, individuals carrying high-risk alleles in this gene have been associated with an increased incidence of negative symptoms for the disease, which include anhedonia, avolition and social withdrawal. Here we evaluated behavioral and neurochemical...
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