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Article

Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder.

Human molecular genetics - 15 Sept 2021

Nakamura Takumi, Nakajima Kazuo, Kobayashi Yuki, Itohara Shigeyoshi, Kasahara Takaoki, Tsuboi Takashi, Kato Tadafumi

Abstract excerpt

Bipolar disorder is a common mental illness occurring in approximately 1% of individuals and requires lifelong treatment. Although genetic factors are known to contribute to this disorder, the genetic architecture has not yet been completely clarified. Our initial trio-based exome sequencing study of bipolar disorder showed enrichment of de novo, loss-of-function (LOF) or protein-altering mutations in a combined...

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Identifiers

PMID: 34100076
DOI: 10.1093/hmg/ddab152
PMCID: PMC8444452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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