Article

A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

2021-06-05

Abstract excerpt

Bipolar disorder is an often-severe mental health disorder characterized by alternation between extreme mood states of mania and depression. Despite strong heritability and the recent identification of 64 loci of small effect, pathophysiological mechanisms and much of the genetic risk remain unknown. Here, through genome sequencing and linkage and association analyses, we found that rare variants co-segregating wi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c009649-dbe8-51d2-8e6e-206a7cabe8e1
DOI: 10.1101/2021.06.02.21258261

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A rare variant in D-amino acid oxidase implicates NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorderDOI 10.1101/2021.06.02.21258261Read

Systematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder.Semantic proximity Read

Rare Genomic Variants Link Bipolar Disorder with Anxiety Disorders to CREB-Regulated Intracellular Signaling PathwaysSemantic proximity Read

Genome-wide association study identifies 30 Loci Associated with Bipolar DisorderSemantic proximity Read

Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder.Semantic proximity Read

Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in bipolar disorder.Semantic proximity Read

Initial association of NR2E1 with bipolar disorder and identification of candidate mutations in bipolar disorder, schizophrenia, and aggression through resequencing.Semantic proximity Read

Whole exome sequencing in the UK Biobank reveals risk gene<i>SLC2A1</i>and biological insights for major depressive disorderSemantic proximity Read

An Integrative Genomic Study Implicates the Postsynaptic Density in the Pathogenesis of Bipolar DisorderSemantic proximity Read

Deregulation of the A-to-I RNA editing mechanism in psychiatric disordersSemantic proximity Read

Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors.Semantic proximity Read

Genomic variants in an inbred mouse model predict mania-like behaviors.Semantic proximity Read

Focus on rare genetic variants in bipolar disorder: how outliers help understand complex disorders.Semantic proximity Read