Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

doi:10.1038/s41467-018-04711-w

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Article

Variations in Dysbindin-1 are associated with cognitive response to antipsychotic drug treatment.

Nature communications - 11 Jun 2018

Scheggia Diego, Mastrogiacomo Rosa, Mereu Maddalena, Sannino Sara, Straub Richard E, Armando Marco, Managò Francesca, Guadagna Simone, Piras Fabrizio, Zhang Fengyu, Kleinman Joel E, Hyde Thomas M, Kaalund Sanne S, Pontillo Maria, Orso Genny, Caltagirone Carlo, Borrelli Emiliana, De Luca Maria A, Vicari Stefano, Weinberger Daniel R, Spalletta Gianfranco, Papaleo Francesco

Abstract excerpt

Antipsychotics are the most widely used medications for the treatment of schizophrenia spectrum disorders. While such drugs generally ameliorate positive symptoms, clinical responses are highly variable in terms of negative symptoms and cognitive impairments. However, predictors of individual responses have been elusive. Here, we report a pharmacogenetic interaction related to a core cognitive dysfunction in...

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Identifiers

PMID: 29891954
DOI: 10.1038/s41467-018-04711-w
PMCID: PMC5995960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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