Article
Dysbindin-1 gene contributes differentially to early- and adult-onset forms of functional psychosis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Apr 2011
Fatjó-Vilas Mar, Papiol Sergi, Estrada Gemma, Bombín Igor, Peralta Victor, Rosa Araceli, Parellada Mara, Miret Salvador, Martín María, Lázaro Luisa, Campanera Sílvia, Muñoz Ma José, Lera-Miguel Sara, Arias Bárbara, Navarro Ma Eulalia, Castro-Fornieles Josefina, Cuesta Manuel J, Arango Celso, Fañanás Lourdes
Abstract excerpt
Dysbindin-1 is a relatively ubiquitous protein in the brain which is involved in the modulation of synaptic homeostasis. The dysbindin-1 gene (DTNBP1) has been associated with schizophrenia and bipolar disorder diagnoses. However, its contribution to the severity of the clinical and neurocognitive expression of these disorders remains controversial. We aimed to explore the association between DTNBP1 and the...
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