Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2.

Abstract excerpt

OBJECTIVE: The LRRK2(G2019S) mutation is the most common identifiable cause for Parkinson disease (PD), but the underlying mechanisms leading to neuronal cell death remain largely unclear. Impaired mitochondrial function and morphology have been described in different in vivo and in vitro model systems of early-onset PD (EOPD) as well as in EOPD patient tissue. The aim of our study was to assess mitochondrial...

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