Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases.

Journal of translational medicine - 7 Jun 2018

Hamdi Yosr, Boujemaa Maroua, Ben Rekaya Mariem, Ben Hamda Cherif, Mighri Najah, El Benna Houda, Mejri Nesrine, Labidi Soumaya, Daoud Nouha, Naouali Chokri, Messaoud Olfa, Chargui Mariem, Ghedira Kais, Boubaker Mohamed Samir, Mrad Ridha, Boussen Hamouda, Abdelhak Sonia

Abstract excerpt

BACKGROUND: A family history of breast cancer has long been thought to indicate the presence of inherited genetic events that predispose to this disease. In North Africa, many specific epidemio-genetic characteristics have been observed in breast cancer families when compared to Western populations. Despite these specificities, the majority of breast cancer genetics studies performed in North Africa remain...

Topics

Female
Humans
Alleles
Breast Neoplasms
Exome Sequencing
Family
Genes, Neoplasm
Genetic Association Studies
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Pedigree

Protein Interaction Maps

Tunisia

Source

Open in PubMed Open full text

Identifiers

PMID: 29879995
DOI: 10.1186/s12967-018-1504-9
PMCID: PMC5992876

Genes

BRCA1
BRCA2
DNAH3
MMS19
POLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases.PMID 29879995Read ↗

The Identification by Exome Sequencing of Candidate Genes in BRCA-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer.Semantic proximity Read ↗

Whole exome sequencing reveals a combination of rare high and low penetrance variants that correlates with familial breast cancer relative riskSemantic proximity Read ↗

Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.Semantic proximity Read ↗

Germline copy number variations in BRCA1/2 negative families: Role in the molecular etiology of hereditary breast cancer in Tunisia.Semantic proximity Read ↗

Unique Features of Germline Variation in Five Egyptian Familial Breast Cancer Families Revealed by Exome Sequencing.Semantic proximity Read ↗

Identification of Eleven Novel BRCA Mutations in Tunisia: Impact on the Clinical Management of BRCA Related CancersSemantic proximity Read ↗

Health influenced by genetics: A first comprehensive analysis of breast cancer high and moderate penetrance susceptibility genes in the Tunisian population.Semantic proximity Read ↗

Integrative Gene-Centric Analysis of Breast Cancer: High-Confidence Germline Predisposition Genes from Population-Scale CohortsSemantic proximity Read ↗

Identification of novel candidate genes by exome sequencing in Tunisian familial male breast cancer patients.Semantic proximity Read ↗

Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast CancerSemantic proximity Read ↗

Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population.Semantic proximity Read ↗

Novel and Recurrent BRCA1/BRCA2 Germline Mutations in Patients with Breast /Ovarian Cancer: A Series from the South of TunisiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.