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The Identification by Exome Sequencing of Candidate Genes in BRCA-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer.

Genes - 22 Jul 2022

BenAyed-Guerfali Dorra, Kifagi Chamseddine, BenKridis-Rejeb Wala, Ammous-Boukhris Nihel, Ayedi Wajdi, Khanfir Afef, Daoud Jamel, Mokdad-Gargouri Raja

Abstract excerpt

(1) Background: Germline variants in BRCA1/BRCA2 genes explain about 20% of hereditary breast/ovarian cancer (HBOC) cases. In the present paper, we aim to identify genetic determinants in BRCA-negative families from the South of Tunisia. (2) Methods: Exome Sequencing (ES) was performed on the lymphocyte DNA of patients negative for BRCA mutations from each Tunisian family with a high risk of HBOC. (3) Results: We...

Topics

Breast Neoplasms
Exome
Female
Genetic Predisposition to Disease
Humans
Ovarian Neoplasms
Exome Sequencing

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35893033
DOI: 10.3390/genes13081296
PMCID: PMC9331434

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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