Article
Health influenced by genetics: A first comprehensive analysis of breast cancer high and moderate penetrance susceptibility genes in the Tunisian population.
PloS one - 1 Jan 2022
Boujemaa Maroua, Mighri Najah, Chouchane Lotfi, Boubaker Mohamed Samir, Abdelhak Sonia, Boussen Hamouda, Hamdi Yosr
Abstract excerpt
Significant advances have been made to understand the genetic basis of breast cancer. High, moderate and low penetrance variants have been identified with inter-ethnic variability in mutation frequency and spectrum. Genome wide association studies (GWAS) are widely used to identify disease-associated SNPs. Understanding the functional impact of these risk-SNPs will help the translation of GWAS findings into...
Topics
- Breast Neoplasms
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- MicroRNAs
- Penetrance
- Polymorphism, Single Nucleotide