Article
Identification of novel candidate genes by exome sequencing in Tunisian familial male breast cancer patients.
Molecular biology reports - 1 Sept 2020
Ben Kridis-Rejeb Wala, Ben Ayed-Guerfali Dorra, Ammous-Boukhris Nihel, Ayadi Wajdi, Kifagi Chamseddine, Charfi Slim, Saguem Ines, Sellami-Boudawara Tahia, Daoud Jamel, Khanfir Afef, Mokdad-Gargouri Raja
Abstract excerpt
Male Breast Cancer (MBC) is a rare and aggressive disease that is associated with genetic factors. Mutations in BRCA1 and BRCA2 account for 10% of all MBC cases suggesting that other genetic factors are involved. The aim of the present study is to screen whole BRCA1 and BRCA2 exons using the Ampliseq BRCA panel in Tunisian MBC patients with family history. Furthermore, we performed exome sequencing using the...
Topics
- Adult
- Aged
- Axonemal Dyneins
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms, Male
- Cell Cycle Proteins
- DCC Receptor
- Formins
- Frameshift Mutation