Article
Unique Features of Germline Variation in Five Egyptian Familial Breast Cancer Families Revealed by Exome Sequencing.
PloS one - 1 Jan 2017
Kim Yeong C, Soliman Amr S, Cui Jian, Ramadan Mohamed, Hablas Ahmed, Abouelhoda Mohamed, Hussien Nehal, Ahmed Ola, Zekri Abdel-Rahman Nabawy, Seifeldin Ibrahim A, Wang San Ming
Abstract excerpt
Genetic predisposition increases the risk of familial breast cancer. Recent studies indicate that genetic predisposition for familial breast cancer can be ethnic-specific. However, current knowledge of genetic predisposition for the disease is predominantly derived from Western populations. Using this existing information as the sole reference to judge the predisposition in non-Western populations is not adequate...
Topics
- Adult
- Aged
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Egypt
- Exome
- Family
- Female
- Genetic Predisposition to Disease
- High-Throughput Nucleotide Sequencing