Article
Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population.
Molecular biology reports - 1 Feb 2012
Mahfoudh Wijden, Bouaouina Noureddine, Ahmed Slim Ben, Gabbouj Sallouha, Shan Jingxuan, Mathew Rebecca, Uhrhammer Nancy, Bignon Yves-Jean, Troudi Wafa, Elgaaied Amel Ben Ammar, Hassen Elham, Chouchane Lotfi
Abstract excerpt
Germ-line mutations in BRCA1 breast cancer susceptibility gene account for a large proportion of hereditary breast cancer families and show considerable ethnic and geographical variations. The contribution of BRCA1 mutations to hereditary breast cancer has not yet been thoroughly investigated in Middle Eastern and North African populations. In this study, 16 Tunisian high-risk breast cancer families were screened...
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