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Article

Insights into the activity of maturation inhibitor PF-46396 on HIV-1 clade C.

Scientific reports - 2 Mar 2017

Ghimire Dibya, Timilsina Uddhav, Srivastava Tryambak Pratap, Gaur Ritu

Abstract excerpt

HIV maturation inhibitors are an emerging class of anti-retroviral compounds that inhibit the viral protease-mediated cleavage of the Gag, CA-SP1 (capsid-spacer peptide 1) peptide to mature CA. The first-in-class maturation inhibitor bevirimat (BVM) displayed potent activity against HIV-1 clade B but was ineffective against other HIV-1 clades including clade C. Another pyridone-based maturation inhibitor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28252110
DOI: 10.1038/srep43711
PMCID: PMC5333120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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