Article
NF1 mutations are recurrent in adult acute myeloid leukemia and confer poor outcome.
Leukemia - 1 Dec 2018
Eisfeld Ann-Kathrin, Kohlschmidt Jessica, Mrózek Krzysztof, Mims Alice, Walker Christopher J, Blachly James S, Nicolet Deedra, Orwick Shelley, Maharry Sophia E, Carroll Andrew J, Powell Bayard L, Kolitz Jonathan E, Wang Eunice S, Stone Richard M, de la Chapelle Albert, Byrd John C, Bloomfield Clara D
Abstract excerpt
Targeted mutation assessment of 81 genes in 1021 adults with de novo acute myeloid leukemia (AML) identified recurrent mutations in the neurofibromin 1 (NF1) gene in 52 (5.1%) patients, including 36 (5.2%) younger and 16 (4.8%) older patients, which suggests NF1 belongs to the 20 most frequently mutated genes in adult AML. NF1 mutations were found throughout the gene, and comprised missense, frameshift, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.