Article
Mutation patterns identify adult patients with de novo acute myeloid leukemia aged 60 years or older who respond favorably to standard chemotherapy: an analysis of Alliance studies.
Leukemia - 1 Jun 2018
Eisfeld Ann-Kathrin, Kohlschmidt Jessica, Mrózek Krzysztof, Blachly James S, Walker Christopher J, Nicolet Deedra, Orwick Shelley, Maharry Sophia E, Carroll Andrew J, Stone Richard M, de la Chapelle Albert, Wang Eunice S, Kolitz Jonathan E, Powell Bayard L, Byrd John C, Bloomfield Clara D
Abstract excerpt
Thus far, only 5-15% of AML patients aged ≥60 years are cured with chemotherapy. Identification of patients who are less (more) likely to respond to standard chemotherapy might enable early risk stratification toward alternative treatment regimens. We used a next-generation sequencing panel of 80 cancer- and/or leukemia-associated genes to profile molecularly 423 older patients with de novo AML. Using variables...
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