Article
Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group.
Blood - 5 Aug 2010
Ho Phoenix A, Zeng Rong, Alonzo Todd A, Gerbing Robert B, Miller Kristen L, Pollard Jessica A, Stirewalt Derek L, Heerema Nyla A, Raimondi Susana C, Hirsch Betsy, Franklin Janet L, Lange Beverly, Meshinchi Soheil
Abstract excerpt
Recent studies of WT1 mutations in acute myeloid leukemia (AML) mostly report an association with unfavorable clinical outcome. We screened 842 patients treated on 3 consecutive pediatric AML trials for WT1 zinc-finger mutations. Eighty-five mutations were detected in 70 of 842 patients (8.3%). Mutations occurred predominantly in exon 7 (n = 74) but were also found in exons 8 (n = 5) and 9 (n = 6). Normal...
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