Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia.

doi:10.1038/s41375-023-02061-1

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Mutated IKZF1 is an independent marker of adverse risk in acute myeloid leukemia.

Leukemia - 1 Dec 2023

Eckardt Jan-Niklas, Stasik Sebastian, Röllig Christoph, Petzold Andreas, Sauer Tim, Scholl Sebastian, Hochhaus Andreas, Crysandt Martina, Brümmendorf Tim H, Naumann Ralph, Steffen Björn, Kunzmann Volker, Einsele Hermann, Schaich Markus, Burchert Andreas, Neubauer Andreas, Schäfer-Eckart Kerstin, Schliemann Christoph, Krause Stefan W, Herbst Regina, Hänel Mathias, Hanoun Maher, Kaiser Ulrich, Kaufmann Martin, Rácil Zdenek, Mayer Jiri, Oelschlägel Uta, Berdel Wolfgang E, Ehninger Gerhard, Serve Hubert, Müller-Tidow Carsten, Platzbecker Uwe, Baldus Claudia D, Dahl Andreas, Schetelig Johannes, Bornhäuser Martin, Middeke Jan Moritz, Thiede Christian

Abstract excerpt

Genetic lesions of IKZF1 are frequent events and well-established markers of adverse risk in acute lymphoblastic leukemia. However, their function in the pathophysiology and impact on patient outcome in acute myeloid leukemia (AML) remains elusive. In a multicenter cohort of 1606 newly diagnosed and intensively treated adult AML patients, we found IKZF1 alterations in 45 cases with a mutational hotspot at N159S....

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PMID: 37833543
DOI: 10.1038/s41375-023-02061-1
PMCID: PMC10681898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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