Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathway

1 Jan 2022

Abstract excerpt

The treatment and prognosis of patients with advanced colorectal cancer (CRC) remain a difficult problem. Herein, we investigated the role of DEAD (Asp-Glu-Ala-Asp) box helicase 3 (DDX3) in CRC and proposed potential therapeutic targets for advanced CRC. Methods: The expression of DDX3 in CRC and its effect on prognosis were explored by databases and CRC tissue microarrays. Stable DDX3 knockdown and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic factors in colorectal cancer
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35844798
DOI: 10.7150/ijbs.73491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DDX3 acts as a tumor suppressor in colorectal cancer as loss of DDX3 in advanced cancer promotes tumor progression by activating the MAPK pathwayPMID 35844798Read ↗

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer.Semantic proximity Read ↗

DDX10 Promotes the Proliferation and Metastasis of Colorectal Cancer Cells via Splicing RPL35Semantic proximity Read ↗

The RNA-binding protein DDX39B promotes colorectal adenocarcinoma progression by stabilizing DCLK1Semantic proximity Read ↗

DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patientsSemantic proximity Read ↗

Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers.Semantic proximity Read ↗

DDX39B contributes to the proliferation of colorectal cancer through direct binding to CDK6/CCND1Semantic proximity Read ↗

The DDX39B/FUT3/TGFβR-I Axis Promotes Tumor Metastasis and EMT in Colorectal CancerSemantic proximity Read ↗

Genomic analyses identify significant biological processes in DDX21-mediated colorectal cancer cellsSemantic proximity Read ↗

DDX3X Biomarker Correlates with Poor Survival in Human GliomasSemantic proximity Read ↗

Hypomethylation induced overexpression of PLOD3 facilitates colorectal cancer progression through TM9SF4-mediated autophagySemantic proximity Read ↗

DDX31: A Novel Functional Oncogene Promotes Migration and Proliferation of Pancreatic CancerSemantic proximity Read ↗

DDX17 induces epithelial-mesenchymal transition and metastasis through the miR-149-3p/CYBRD1 pathway in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.