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Article

Epigenetic silencing of CHD5, a novel tumor‐suppressor gene, occurs in early colorectal cancer stages

14 Nov 2013

Abstract excerpt

BACKGROUND: Chromodomain helicase DNA binding protein 5 (CHD5) is a family member of chromatin remodeling factors. The epigenetic silencing mechanisms of CHD5 in colorectal cancer have not been well studied. METHODS: Here we analyzed CHD5 methylation and mRNA expression in vitro and in clinical samples from African American patients. DNA and RNA were isolated from formalin fixed paraffin embedded (FFPE) colon...

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PMID: 24243398
DOI: 10.1002/cncr.28316

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