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Article

DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis

1 Jan 2022

Abstract excerpt

Rationale: Doublecortin-like kinase 1 (DCLK1) is a serine/threonine kinase that selectively marks cancer stem-like cells (CSCs) and promotes malignant progression in colorectal cancer (CRC). However, the exact molecular mechanism by which DCLK1 drives the aggressive phenotype of cancer cells is incompletely determined. Methods: Here, we performed comprehensive genomics and proteomics analyses to identify binding...

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PMID: 35910805
DOI: 10.7150/thno.72037

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