Article
Requirement of the IL-2 receptor beta chain for the development of Vgamma3 dendritic epidermal T cells.
The Journal of investigative dermatology - 1 Jun 1998
Kawai K, Suzuki H, Tomiyama K, Minagawa M, Mak T W, Ohashi P S
Abstract excerpt
Vgamma3 TCR cells develop in the fetal thymus and migrate to the skin as dendritic epidermal T cells (DETC). Fetal Vgamma3 thymocytes differentiate from immature heat stable antigen (HSA)high cells to mature HSAlow cells and the latter subset predominantly expresses IL-2 receptor beta chain (IL-2Rbeta). In this study, the role of IL-2Rbeta in the development of Vgamma3 cells was determined in IL-2Rbeta-deficient...
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