Article
Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity.
Nature communications - 4 Jun 2018
Merks Anne Margarete, Swinarski Marie, Meyer Alexander Matthias, Müller Nicola Victoria, Özcan Ismail, Donat Stefan, Burger Alexa, Gilbert Stephen, Mosimann Christian, Abdelilah-Seyfried Salim, Panáková Daniela
Abstract excerpt
Development of a multiple-chambered heart from the linear heart tube is inherently linked to cardiac looping. Although many molecular factors regulating the process of cardiac chamber ballooning have been identified, the cellular mechanisms underlying the chamber formation remain unclear. Here, we demonstrate that cardiac chambers remodel by cell neighbour exchange of cardiomyocytes guided by the planar cell...
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