Article

Human bone marrow disorders recapitulated in vitro using organ chip technology

2018-11-01

Abstract excerpt

Understanding human bone marrow (BM) pathophysiology in the context of myelotoxic stress induced by drugs, radiation, or genetic mutations is of critical importance in clinical medicine. However, study of these dynamic cellular responses is hampered by the inaccessibility of living BM in vivo . Here, we describe a vascularized human Bone Marrow-on-a-Chip (BM Chip) microfluidic culture device for modeling bone mar...

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Literature Corpus work: 4ba8b037-a94e-56d4-bab5-54703829560a
DOI: 10.1101/458935

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