Article
Impaired Photic Entrainment of Spontaneous Locomotor Activity in Mice Overexpressing Human Mutant α-Synuclein.
International journal of molecular sciences - 3 Jun 2018
Pfeffer Martina, Zimmermann Zuzana, Gispert Suzana, Auburger Georg, Korf Horst-Werner, von Gall Charlotte
Abstract excerpt
Parkinson's disease (PD) is characterized by distinct motor and non-motor symptoms. Sleep disorders are the most frequent and challenging non-motor symptoms in PD patients, and there is growing evidence that they are a consequence of disruptions within the circadian system. PD is characterized by a progressive degeneration of the dorsal vagal nucleus and midbrain dopaminergic neurons together with an imbalance of...
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