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Article

Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice.

Neurobiology of disease - 1 Feb 2006

Unger Erica L, Eve David J, Perez Xiomara A, Reichenbach Dawn K, Xu Yanqun, Lee Michael K, Andrews Anne M

Abstract excerpt

Genetic and biochemical abnormalities associated with alpha-synuclein are implicated in the etiology of Parkinson's disease (PD). In this study, altered locomotor behavior linked to the expression of mutant or wildtype human alpha-synuclein was investigated. A53T alpha-synuclein transgenic (A53T-tg) mice exhibited normal activity at 5 months of age; however, by 7 months, they developed marked hyperactivity that...

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Identifiers

PMID: 16230020
DOI: 10.1016/j.nbd.2005.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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