Article
Mutant α-synuclein enhances firing frequencies in dopamine substantia nigra neurons by oxidative impairment of A-type potassium channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Oct 2014
Subramaniam Mahalakshmi, Althof Daniel, Gispert Suzana, Schwenk Jochen, Auburger Georg, Kulik Akos, Fakler Bernd, Roeper Jochen
Abstract excerpt
Parkinson disease (PD) is an α-synucleinopathy resulting in the preferential loss of highly vulnerable dopamine (DA) substantia nigra (SN) neurons. Mutations (e.g., A53T) in the α-synuclein gene (SNCA) are sufficient to cause PD, but the mechanism of their selective action on vulnerable DA SN neurons is unknown. In a mouse model overexpressing mutant α-synuclein (A53T-SNCA), we identified a SN-selective increase...
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