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Article

DMSO increases efficiency of genome editing at two non-coding loci.

PloS one - 1 Jan 2018

Stratigopoulos George, De Rosa Maria Caterina, LeDuc Charles A, Leibel Rudolph L, Doege Claudia A

Abstract excerpt

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein-9 (Cas9) has become the tool of choice for genome editing. Despite the fact that it has evolved as a highly efficient means to edit/replace coding sequence, CRISPR/Cas9 efficiency for "clean" editing of non-coding DNA remains low. We set out to introduce a single base-pair substitution in two intronic SNPs at the FTO...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29864154
DOI: 10.1371/journal.pone.0198637
PMCID: PMC5986138

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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