Article

Frame Editors for Precise, Template-Free Frameshifting

2022-12-05

Abstract excerpt

Efficiency and accuracy are paramount in genome editing. While CRISPR-Cas nucleases are efficient at editing target genes, their accuracy is limited because following DNA cleavage by Cas proteins, error-prone repair mechanisms introduce random mutations. Improving the accuracy of CRISPR-Cas by reducing random repairs using DNA- or RNA-based templates can compromise efficiency. To simultaneously improve both editin...

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Literature Corpus work: 5aac07e2-d6ab-5de8-bbdd-8cd02120d0e6
DOI: 10.1101/2022.12.05.518807

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