Article

Dysregulation of neuronal activity-dependent immediate early genes in a mouse model of Angelman syndrome

2025-04-19

Abstract excerpt

<h4>Summary</h4> Angelman syndrome (AS) is a debilitating neurodevelopmental disorder triggered by impaired function of the maternal UBE3A gene, which codes a protein that functions as a ubiquitin ligase and transcriptional coactivator. Ube3a maternal deficient mice replicate many key behavioral deficits associated with AS; however, the underlying molecular mechanisms remain poorly understood. Using an RT 2 Pro...

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Literature Corpus work: 5fd634ee-4e0f-5a0e-a0ee-e4f33eea63a5
DOI: 10.1101/2025.04.15.648865

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