Article
The role of monogenic disease in children with very early onset inflammatory bowel disease.
Current opinion in pediatrics - 1 Oct 2017
Kelsen Judith R, Baldassano Robert N
Abstract excerpt
PURPOSE OF REVIEW: Inflammatory bowel disease (IBD) is a multifactorial disease caused by dysregulated immune responses to commensal or pathogenic intestinal microbes, resulting in chronic intestinal inflammation. Patients diagnosed with IBD occurring before the age of 5 are a unique population, known as very early onset (VEO)-IBD and can be phenotypically and genetically distinct from older-onset IBD. We aim to...
Topics
- Age of Onset
- Child, Preschool
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Testing
- Genetic Variation
- Humans
- Inflammatory Bowel Diseases
- Phenotype
- Severity of Illness Index
- Exome Sequencing