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Article

TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation.

The Journal of cell biology - 5 Jun 2017

Byrnes Amy E, Slep Kevin C

Abstract excerpt

XMAP215, CLASP, and Crescerin use arrayed tubulin-binding tumor overexpressed gene (TOG) domains to modulate microtubule dynamics. We hypothesized that TOGs have distinct architectures and tubulin-binding properties that underlie each family's ability to promote microtubule polymerization or pause. As a model, we investigated the pentameric TOG array of a Drosophila melanogaster XMAP215 member, Msps. We found...

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Identifiers

PMID: 28512144
DOI: 10.1083/jcb.201610090
PMCID: PMC5461023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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